[Pre-print] Membrane introduction mass spectrometry (MIMS): A versatile tool for direct, real-time chemical measurements
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Issue Date
2014-12
Authors
Krogh, Erik T.
Gill, Chris G.
License
Subject
Abstract
Membrane introduction mass spectrometry (MIMS) is a direct, continuous, online
measurement technique. It utilizes a membrane to semi-selectively transfer
analyte mixtures from a sample to a mass spectrometer, rejecting the bulk of the
sample matrix, which can be a gas, liquid or solid/slurry. Analyte selectivity and
sensitivity is affected by optimizations at the membrane, ionization and the mass
spectrometer levels. MIMS can be roughly classified by the acceptor phase that
entrains analyte(s) to the mass spectrometer after membrane transport, either a
gaseous acceptor phase (GP-MIMS) or condensed acceptor phase (CP-MIMS).
The aim of this article is to provide an introduction to MIMS as a technique and to
explore current variants, recent developments and modern applications,
emphasizing examples from our group, the Applied Environmental Research
Laboratories as well as selected work from others in this emerging area. Also
provided is a synopsis of current and future directions for this versatile analytical
technique.